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Experimental Nuclear Magnetic Resonance Conference

The premier magnetic resonance conference.
APRIL 12 - 16, 2026  |  ASILOMAR CONFERENCE CENTER

          

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Early Morning Lecture Series

Hyperpolarization Parts 1 - 4

Sensitivity enhancement, by means of nuclear hyperpolarization, is a critical step in many contemporary magnetic resonance experiments. In this series of four lectures, I will focus on methods of microwave-driven hyperpolarization (dynamic nuclear polarization or DNP) and hyperpolarization initiated by light-excitation. I will describe physical principles, instrumentation, polarizing agents, and numerical simulation. The strengths and weaknesses of various approaches will be discussed, with an eye on applications in spectroscopy and imaging.

  • Monday, 7:00-7:50 AM, Merrill Hall - Part 1
    How the steady-state solution of a set of coupled rate equations led to identification of natural products at natural abundance and process monitoring.

  • Tuesday, 7:00-7:50 AM, Merrill Hall - Part 2
    Magic-angle spinning (MAS) enables NMR spectroscopy of solids. DNP has helped MAS NMR come into its own, making possible the atomic-level structural investigation of complex materials and biosolids.

  • Wednesday, 7:00-7:50 AM, Merrill Hall - Part 3
    Microwave pulse sequences offer the prospect of more efficient as well as more flexible transfer of polarization. Dissolution or melting after hyperpolarization yields hyperpolarized water, sensitive metabolic imaging, and fast ligand screening.

  • Thursday, 7:00-7:50 AM, Merrill Hall - Part 4
    Can light-excitation deliver still higher sensitivity at a reduced footprint? will cover microwave pulse sequences offer the prospect of more efficient as well as more flexible transfer of polarization. Dissolution or melting after hyperpolarization yields hyperpolarized water, sensitive metabolic imaging, and fast ligand screening.

Guinevere Mathies
University of Konstanz

 

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