Code: FOA	Time Slot/Poster Number: 08:30-08:55	Session: Instrumentation
1 mm MAS
Ago Samoson
NICPB, Tallinn, Estonia
Abstract
We demonstrate NMR experiments at spinning frequencies above 80 kHz. 1H spectrum of adamantane shows 1:3 splitting of 0.1 ppm, at high rotation speeds the sample provides excellent for shimming and angle fine-tuning. Centrifugal 1 mm rotor green body formation is described. Implications of fastMAS on spin-diffusion are discussed.

Code: FOA	Time Slot/Poster Number: 08:55-09:10	Session: Instrumentation
Practical Aspects of Boosting Sensitivity with Inductively Coupled Microcoils
Joel A Tang; Alexej Jerschow
New York University, New York, NY
Abstract
Sensitivity enhancement by the use of inductively coupled mini- and microcoils was demonstrated in solid- and liquid-state NMR. Here, we discuss the practical aspects of using inductively-coupled solenoid coils of different sizes in a liquid-state NMR spectrometer. The sensitivity and resolution enhancements from these resonant coils, with sizes ranging between 3.0 and 0.75 mm i.d., are measured for 23Na single pulse and multidimensional imaging experiments and compared to the results obtained with the conventional liquids NMR 5.0 mm saddle coil. A significant enhancement in sensitivity is observed for both single pulse and imaging experiments. The advantages of this method would be especially useful for spectroscopy and imaging of concentration and/or size-limited samples such as biological tissues.

Code: FOA	Time Slot/Poster Number: 09:10-09:35	Session: Instrumentation
One-sided magnets and spinning coils for magnetic resonance spectroscopy and imaging
Dimitrios Sakellariou1; Cedric Hugon1; Alan Wong1; Pedro Aguiar1; Francesca d'Amico1; Guy Aubert3; Jacques-François Jacquinot2
1CEA Saclay - DSM/IRAMIS/SIS2M/LSDRM, Gif-Sur-Yvette, France; 2CEA Saclay - DSM/IRAMIS/SPEC, Gif-Sur-Yvette, France; 3CEA Saclay - DSM/IRFU, Gif-Sur-Yvette, France
Abstract
A novel theoretical analytical framework that allows the design of arbitrarily uniform permanent magnets, will be presented. We have applied this methodology to the design of one-sided and enclosed magnet systems and performed experimental measurements for their characterization. A discussion involving theoretical and practical issues will be presented in the context of high-resolution MR systems. I will also be presenting recent developments in MR microscopy using micro-coils rotating at the magic angle. Eddy current effects will be discussed and quantified. We will also present applications in biological samples as well as inorganic materials.

Code: FOA	Time Slot/Poster Number: 09:35-09:50	Session: Instrumentation
Defeating Radiation Damping and Static Field Inhomogeneity with Spatially Encoded Noise
Carl A. Michal
University of British Columbia, Vancouver, Canada
Abstract
We present a simple strategy for allowing the collection of high-resolution spectra under conditions where radiation damping would cause distortion and broadening. A strong gradient and selective pulse are used to spatially encode a pseudo-random noise signature into the sample magnetization. A spin-echo followed by a reduced gradient allows acquisition of a deterministically noise-broadened spectrum that can then be faithfully deconvoluted using the intended spatial noise broadening. Examples showing nearly an order of magnitude improvement in solvent line widths are shown. In the presence of a one-dimensional magnetic field inhomogeneity, the same pulse sequence allows extraction of a field map and high-resolution spectra. Strategies for extending the technique to three dimensions will also be discussed.

Code: FOA	Time Slot/Poster Number: 09:50-10:15	Session: Instrumentation
Switched angle spinning NMR: hardware and experiments for oriented membrane systems
Rachel W. Martin; Rebecca Shapiro; Ilya Litvak; Catalina Espinosa; Amanda Brindley
UC Irvine, Irvine, CA
Abstract
Recent work in our group focuses on optimizing SAS hardware and methods for measuring scaled dipolar couplings in oriented membrane systems. Here we describe a prototype 500 MHz 1H-13C double-resonance SAS probe optimized for oriented membrane systems. It incorporates a transverse, high-homogeneity radiofrequency coil that moves with the sample in order to maximize the filling factor and a pneumatic switching system. We have used simulations (using SPINEVOLUTION) and experiments to investigate the modulation of dipolar couplings under different spinning angles in systems with varying degrees of alignment. We will present data from model systems in both thermotropic liquid crystals and stabilized DHPC/DMPC bicelles. Perspectives for future extensions to more dimensions and increasingly complicated systems will also be discussed.